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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Cancer Prev Res (Phila). 2015 Sep 17;8(12):1138–1145. doi: 10.1158/1940-6207.CAPR-15-0175

Table 2.

Overall and colorectal cancer-specific mortality according to quartiles of prediagnostic plasma adiponectin

Quartiles of plasma adiponectina
Variable 1 2 3 4 Ptrendb
Overall mortality (n=621)
No. of events/ No. at risk 75/196 54/134 63/151 77/140
Age-adjusted HR 1 0.98 1.06 1.39 0.07
95% CI Referent 0.69–1.40 0.75–1.48 1.01–1.92
MV-adjusted HR 1 0.91 1.04 1.51 0.024
95% CIc Referent 0.63–1.31 0.73–1.48 1.08–2.12
MV-adjusted HR 1 0.94 1.05 1.70 0.007
95% CId Referent 0.65–1.35 0.73–1.52 1.18–2.44
MV-adjusted HR 1 0.94 1.09 1.68 0.007
95% CIe Referent 0.65–1.36 0.75–1.57 1.16–2.41
MV-adjusted HR 1 0.94 1.08 1.66 0.009
95% CIf Referent 0.65–1.36 0.75–1.56 1.15–2.39
CRC-specific mortality (n=621)
No. of events/ No. at risk 49/196 38/134 44/151 50/140
Age-adjusted HR 1 1.12 1.15 1.54 0.025
95% CI Referent 0.73–1.72 0.76–1.74 1.03–2.29
MV-adjusted HR 1 1.10 1.18 1.77 0.013
95% CIc Referent 0.71–1.71 0.76–1.83 1.16–2.68
MV-adjusted HR 1 1.17 1.24 1.97 0.006
95% CId Referent 0.75–1.85 0.78–1.97 1.25–3.09
MV-adjusted HR 1 1.19 1.24 1.92 0.008
95% CIe Referent 0.76–1.87 0.78–1.97 1.23–3.02
MV-adjusted HR 1 1.18 1.24 1.89 0.01
95% CIf Referent 0.75–1.86 0.78–1.98 1.21–2.97
a

Quartiles of plasma adiponectin were calculated separately within each cohort based on the distribution among controls based on previously collected data.

b

Tests for linear trend were conducted using the median values for each quartile of adiponectin.

c

Multivariate models were stratified by age at diagnosis, and adjusted for date of blood draw, sex, site of primary cancer (colon vs. rectum), stage at diagnosis and histological grade of cancer (well, moderate, poor/unknown).

d

Multivariate models were stratified by age at diagnosis, and adjusted for date of blood draw, sex, site of primary cancer (colon vs. rectum), stage at diagnosis, histological grade of cancer (well, moderate, poor/unknown), body mass index (BMI), physical activity (metabolic equivalent task score hours per week (METS)), current or past smoking (yes or no), folate, calcium, alcohol, servings of red meat as a main dish, history of colorectal cancer in parent or sibling, and regular use of aspirin or NSAIDs (≥ 2 tablets per week).

e

Multivariate models additionally adjusted for plasma CRP, sTNFR2 and IL-6, as well as the factors listed in d.

f

Multivariate models additionally adjusted for plasma IGF-1/IGFBP-3, as well as the factors listed in e.