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(a) AMOR: (1) anti-BMP-2 mAb is immobilized on a scaffold. (2) mAb captures endogenous BMP-2 (and other homologous osteogenic BMPs) from the microenvironment. (3) BMP-2 captured by specific mAb binds its cellular receptor on osteoprogenitor cells, promoting their osteogenic differentiation. (b) Schematic representation of the binding of the immune complex (IC) between Protein G/anti-BMP-2 mAb/BMP’s to cellular receptors in vivo.
