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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: J Biomater Appl. 2015 Jun 18;30(4):435–449. doi: 10.1177/0885328215590967

Figure 6. Histological sections from synovium and popliteal lymph node (PLN) representative of all treatment groups.

Figure 6

A - H&E stained synovium section after 4 weeks (40× magnification). Diffusely thickened intima, multifocal areas of prominent hyperplasia (arrows). Subintimal inflammation present consistent with ongoing healing. Fibrosis slightly increased. B - H&E stained popliteal lymph node section after 4 weeks (40× magnification). Prominent sinus histiocytosis consistent with mild lymphadenopathy as a result of draining inflammation from implant site, not considered an adverse reaction. C - H&E stained synovium section after 6 weeks (40× magnification).Still multifocal areas of hyperplasia (arrows), but overall intima thin and lined by 1–2 cells as seen in control tissues. Subintimal fibrosis remained increased (dashed line). D - H&E stained popliteal lymph node after 6 weeks (40× magnification). Mild follicular and paracortical and sinus histiocytosis. E - H&E stained synovium section after 8 weeks (40× magnification). Resolution of intimal hyperplasia, subintimal fibrosis and inflammation. Collagen fibers approach thin intimal layer.F - H&E stained popliteal lymph node section at 8 weeks after bio-enhanced ACL repair 40× magnification for a general view. Follicular and paracortical and sinus histiocytosis continues to resolve.