Table 2.
Criteria used to score the anterior cruciate ligament, synovium, and popliteal lymph node
| ANTERIOR CRUCIATE LIGAMENT |
SYNOVIUM | POPLITEAL LYMPH NODE | |||
|---|---|---|---|---|---|
| CRITERIA | pts | CRITERIA | pts | CRITERIA | pts |
| INFLAMMATION (Macrophages, polymorphonuclear, plasma, giant cells) | INFLAMMATION (Macrophages, polymorphonuclear, plasma, giant cells) | SINUS HISTIOCYTOSIS | |||
| None | 0 | ||||
| Minimal | 1 | ||||
| None observed | 0 | None | 0 | Mild | 2 |
| Rare, 1–5/40× field | 1 | Minimal – Scattered small aggregates | 1 | Moderate | 3 |
| 5–10/40× field | 2 | Mild – More numerous small aggregates or diffuse infiltration by small numbers of cells | 2 | Severe | 4 |
| Heavy Infiltrate | 3 | ||||
| Packed | 4 | FOLLICULAR HYPERPLASIA | |||
| Moderate – Numerous large aggregates or diffuse infiltration by a large number of cells | 3 | None | 0 | ||
| NEOVASCULARIZATION | Minimal | 1 | |||
| None | 0 | Mild | 2 | ||
| Minimal capillary proliferation, focal, 1–3 buds | 1 | Marked – Diffuse infiltration by large numbers of cells | 4 | Moderate | 3 |
| Severe | 4 | ||||
| Groups of 4–7 capillaries with supporting fibroelastic structures | 2 | ||||
| NEOVASCULARIZATION | |||||
| Broad band of capillaries with supporting structures | 3 | 0–10 vascular formations/60× field | 0 | ||
| 11–15 vascular formations/60× field | 1 | ||||
| Extensive band of capillaries with fibroelastic structures | 4 | 16–20 vascular formations/60× field | 2 | ||
| 21–25 vascular formations/60× field | 3 | ||||
| 26–30 vascular formations/60× field | 4 | ||||
| FIBROSIS | |||||
| None | 0 | FIBROSIS | |||
| Narrow band | 1 | None | 0 | ||
| Moderately thick band | 2 | Minimal subintimal fibrosis – loose wavy fibers separated by edema | 1 | ||
| Thick band | 3 | ||||
| Extensive band | 4 | Mild subintimal fibrosis – thicker and more organized fibers extending slightly further from the synoviocyte lining layer | 2 | ||
| FATTY INFILTRATE | |||||
| None | 0 | Moderate subintimal fibrosis – thick bands of fibrosis extending subintimally | 3 | ||
| Minimal amount of fat associated with fibrosis | 1 | ||||
| Marked subintimal fibrosis – diffuse marked fibrosis | 4 | ||||
| Several layers of fat and fibrosis | 2 | ||||
| Elongated and broad accumulation of fat cells at the implant site | 3 | ||||
| SYNOVIAL HYPERPLASIA | |||||
| Extensive fat completely surrounding the implant | 4 | Normal synoviocyte lining layer, 1–2 cell layers thick | 0 | ||
| Minimal hyperplasia – Focal areas of synoviocyte hyperplasia that are 3–4 cell layers thick | 1 | ||||
| Mild hyperplasia – Diffusely 3–4 cell layers thick +/− focal areas up to 5 cell layers thick | 2 | ||||
| Moderate hyperplasia – Diffusely 5–7 cell layers thick +/− focal areas up to 10 layers thick | 3 | ||||
| Marked hyperplasia - Diffusely 8+ cell layers thick | 4 | ||||
pts - points