Table 4.
Change in quantitative measures assessed by pelvic sonography and DEXA from baseline to post-intervention. For quantitative measures, median, range, [interquartile range], and mean ± standard deviation are shown for the 25 subjects. For categorical indices, the number and percentage are shown.
| Variable or Biomarker | Baseline | Post-Intervention | Change | P-value |
|---|---|---|---|---|
| Pelvic Ultrasonography | ||||
| Endometrial thickness, mm | 6 2 – 26 [4 – 9] 7.6 ± 5.5 |
6 1 – 17 [3.5 – 8] 6.3 ± 4.0 |
0.0 −11 – 5 [−3 – 2] −0.7 ± 3.9 |
0.40 |
| Endometrial evaluation as Abnormal | 0% | 0% | 0% | 1.00 |
| Ovarian Cyst largest diameter, mm | 12 0 – 26 [0 – 19] 10.5 ± 9.5 |
23 0 – 54 [16 – 35.5] 25.6 ± 14.4 |
14 −19 – 49 [3.5 – 24.5] 15.1 ± 15.4 |
<0.001 |
| Ovarian Cysts Present Any | 15 (60%) | 23 (92%) | 8 (32%) | 0.011 |
| > 30 mm | 0 (0%) | 9 (36%) | 9 (36%) | 0.003 |
| Fibroid largest diameter, mm | 0 0 – 16 [0 – 0] 2.3 ± 5.5 |
0 0 – 25 [0 – 0] 1.8 ± 6.3 |
0 −15 – 9 [0 – 0] −0.52 ± 4.4 |
0.47 |
| Fibroids Present | 4 (16%) | 2 (8%) | 2 (8%) | 0.16 |
| DEXA | ||||
| Lumbar Spine Bone Mineral Density, g/cm2 | 1.28 1.09 – 1.48 [1.19 – 1.37] 1.28 ± 0.11 |
1.24 1.07 – 1.42 [1.17 – 1.30] 1.24 ± 0.09 |
−0.05 −0.11 – 0.03 [−0.07 – −0.02] −0.05 ± 0.04 |
<0.001 |
| Lumbar Spine T-Score | 0.70 −0.8 – 2.3 [0 – 1.4] 0.69 ± 0.84 |
0.30 −1.2 – 1.9 [−0.25 – 0.9] 0.30 ± 0.78 |
−0.40 −1.1 – 0.3 [−0.6 – −0.2] −0.39 ± 0.30 |
<0.001 |
| Femur Bone Mineral Density, g/cm2 | 0.99 0.80 – 1.28 0.94[− 1.15] 1.04 ± 0.13 |
1.03 0.88 – 1.35 [0.95 – 1.18] 1.05 ± 0.14 |
−0.01 −0.06 – 0.36 [−0.02 – 0.01] 0.016 ± 0.08 |
0.48 |
| Femur T-Score | −0.2 −1.7 – 2.2 [−0.6 – 1.1] 0.25 ± 1.03 |
−0.1 −1.1 – 2.7 [−0.5 – 1.4] 0.36 ± 1.10 |
−0.1 −0.60 – 2.90 [−0.2 – 0.1] 0.11 ± 0.69 |
0.68 |
| Percent Body Fat | 35.8 16.7 – 54.2 [31.3 – 46.1] 37.0 ± 9.4 |
37.5 19.3 – 54.7 [31.2 – 46.7] 37.8 ± 9.9 |
0.3 −4.0 – 5.8 [−1.7 – 2.4] 0.3 ± 2.6 |
0.76 |