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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Biol Psychiatry. 2015 Jun 6;79(11):898–905. doi: 10.1016/j.biopsych.2015.05.022

Figure 2.

Figure 2

Bidirectional effect of cocaine on evoked uEPSCs at single spines of D1- and D2-MSNs. (A) Schematic outlining the experimental timeline for cocaine administration and MNI-glutamate uncaging. (B) A summary plot of the effect of cocaine on the percent of responsive and unresponsive thin spines. (C, D) Representative traces with the summary of average data points of uncaging-evoked uEPSC amplitudes in mushroom and thin spines after saline or cocaine treatment in D1-MSNs (C) and D2-MSNs (D). (E) Cumulative frequency plot of uncaging-evoked uEPSCs from mushroom spines of D1-MSNs after a saline or a cocaine treatment. (F) Cumulative frequency plot of uncaging-evoked uEPSCs from mushroom spines of D2-MSNs after a saline or a cocaine treatment.