Table 1.
Hemodynamic variables before vehicle or PD123319 administration and body, uterus, and kidney weights at postmortem.
| Group | BW g |
UW mg |
KW g |
MAP mmHg |
RPP mmHg |
RBF mL/min/g KW |
RVR mmHg/mL/min/g KW |
|---|---|---|---|---|---|---|---|
| OV | 192 ± 8 | 35 ± 4 | 0.66 ± 0.03 | 103 ± 6 | 94 ± 6 | 2.7 ± 0.3 | 35 ± 3 |
| OV + PD | 203 ± 11 | 45 ± 12 | 0.70 ± 0.03 | 106 ± 2 | 99 ± 2 | 2.9 ± 0.4 | 37 ± 6 |
| OV + E | 185 ± 9 | 202 ± 19∗ | 0.62 ± 0.03 | 100 ± 4 | 91.7 ± 3 | 2.1 ± 0.1 | 44 ± 1 |
| OV + E + PD | 183 ± 6 | 201 ± 26∗ | 0.72 ± 0.04 | 109 ± 5 | 102 ± 4 | 2.5 ± 0.2 | 44 ± 2 |
| Sham | 190 ± 4 | 107 ± 7# | — | — | — | — | |
|
| |||||||
| P ANOVA | 0.4 | <0.0001 | 0.2 | 0.5 | 0.3 | 0.2 | 0.3 |
Data are presented as mean ± SEM of n = 5. The P values were derived from one-way ANOVA. Specific contrasts were generated by Tukey's post hoc comparisons. ∗ P ≤ 0.05 for comparison with ovariectomized rats treated with the vehicles for estrogen and PD123319. # P ≤ 0.05 for comparison with all ovariectomized rats. OV: ovariectomized, E: estradiol, PD: PD123319, BW: body weight, UW: uterus weight, KW: kidney weight, MAP: mean arterial pressure, RPP: renal perfusion pressure, RBF: renal blood flow per gram kidney weight, and RVR: renal vascular resistance.