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. 2015 Nov 19;6(11):e1990. doi: 10.1038/cddis.2015.290

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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SOX4 regulated the expression of ABCG2 in SOX4-modified CaSki cells. RT-PCR (a), qRT-PCR (b) and western blot (c) analysis of the effect of SOX on ABCG2 mRNA and protein expression. (d) Immunohistochemistry analysis of SOX4 and ABCG2 expression in tumor xenografts from the mice implanted with CaSki/Mock and CaSki/SOX4 cells (× 400). (e) The diagram of SOX4-binding site with ABCG2. In the gene diagram, the ABCG2 gene (horizontal line) and base position (vertical lines) are drawn to scale. Data were shown as the mean±S.E.M. *P<0.05