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. 2015 Nov 19;6(11):e1984. doi: 10.1038/cddis.2015.337

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Eighteen-month-old Smad4^co/co;Lck-Cre mice exhibit impaired CD44 expression in CD8⁺ T cells. (a) Genotyping of Smad4^co/co;Lck-Cre mice (Cre/Co/Co) and control littermates (Co/Co). (b) The expression of Smad4 and actin in the thymocytes of 6- to 8-week-old Smad4^co/co;Lck-Cre mice and control littermates. IB, immunoblotting. (c) Flow cytometry analysis of Smad4 expression in splenic CD4⁺ T, CD8⁺ T, Gr1⁺, and CD19⁺ B cells of 6- to 8-week-old Smad4^co/co;Lck-Cre mice and control littermates. (d) The absolute numbers of total white cells, CD4⁺ T, and CD8⁺ T cells in the spleen, as revealed by white cell count and flow cytometry analysis, in 18-month-old Smad4^co/co;Lck-Cre mice and control littermates (n=6 per group). (e) Flow cytometry analysis of CD44 expression in CD4⁺ and CD8⁺ T cells in the spleen and mesenteric lymph node (mLN) of 18-month-old Smad4^co/co;Lck-Cre mice and control littermates (n=6 per group)