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. 2015 Nov 19;6(11):e1984. doi: 10.1038/cddis.2015.337

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Smad4 contributes to the differentiation of central memory T cells by promoting the survival of MPECs. (a and b) The expression of CD62L and CD27 in K^b-ova⁺CD8⁺CD127^hiKLRG1^low splenic T cells of Smad4^co/co;Lck-Cre mice and their littermate controls on day 10 (a) or day 21 (b) of LM-OVA primary infection (n=6 per group). (c) Apoptosis analysis of K^b-ova⁺CD8⁺CD127^hiKLRG1^low splenic T cells of Smad4^co/co;Lck-Cre mice and their littermate controls on days 10 and 14 of LM-OVA primary infection (n=6 per group). Data shown in this figure are representative of at least three independent experiments