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. 2015 Nov 26;6(11):e1993. doi: 10.1038/cddis.2015.338

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The inhibition of DC maturation by CHBP is mediated by Jak-2/STAT3/SOCS1 signaling. Cells were cultured for 8 days to induce imDCs and LPS was added in the culture system for another 24 h to induce mDCs. (a) The expression of Jak-2, p-STAT3, NF-κB, TLR-2, TLR-4 and IRAK1 was examined by western blotting in BM-derived DC maturation model. (b) Semiquantitative analysis for western blotting was shown. (c) The expression of p-STAT3, NF-κB, TLR-2, TLR-4 and IRAK1 was examined by western blotting in LPS-induced DCs maturation model. (d) Semiquantitative analysis for western blotting was shown. Results are mean±S.D. from three independent experiments. (a and c) Representative images from one experiment out of three are shown