Table 7.
Bioavailability and drug-likeness predictions of substances 4–17 in addition to Acarbose and Gliclazide.
| Cpd. No. | Lipinski (violations) | Veber (violations) | Ghose (violations) | Egan (violations) | Muegge (violations) | Bioavailability Score | PAINS alerts | Synthetic Accessibility |
|---|---|---|---|---|---|---|---|---|
| 4 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 3.44 |
| 5 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 3.54 |
| 6 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 3.7 |
| 7 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 3.43 |
| 8 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 3.56 |
| 9 | 0 | 0 | 0 | 0 | 1 | 0.55 | 0 | 3.75 |
| 10 | 0 | 0 | 0 | 0 | 0 | 0.55 | 1 | 3.66 |
| 12 | 1 | 0 | 3 | 1 | 3 | 0.55 | 1 | 4.78 |
| 13 | 1 | 0 | 3 | 1 | 3 | 0.55 | 1 | 4.78 |
| 14 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 3.03 |
| 15 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 3.99 |
| 16 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 4.09 |
| 17 | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 4.09 |
| Acarbose | 3 | 1 | 4 | 1 | 5 | 0.17 | 0 | 7.34 |
| Gliclazide | 0 | 0 | 0 | 0 | 0 | 0.55 | 0 | 3.52 |