Table 8.

Pharmacokinetic/ADME properties of the tested novel compounds.

Cpd. No.	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
4	High	No	No	Yes	Yes	Yes	No	Yes
5	High	No	No	Yes	Yes	Yes	No	Yes
6	High	No	No	Yes	Yes	Yes	No	Yes
7	High	No	No	Yes	Yes	Yes	No	Yes
8	High	No	No	Yes	Yes	Yes	No	Yes
9	Low	No	No	No	Yes	Yes	No	Yes
10	High	No	No	Yes	No	No	No	Yes
12	Low	No	No	No	No	No	No	No
13	Low	No	No	No	No	No	No	No
14	High	No	No	Yes	No	Yes	No	Yes
15	High	No	No	Yes	Yes	Yes	No	Yes
16	High	No	No	Yes	Yes	Yes	No	Yes
17	High	No	No	Yes	Yes	Yes	No	Yes
Acarbose	Low	No	Yes	No	No	No	No	No
Gliclazide	High	No	Yes	No	No	No	No	No