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Toxicity of the most promising hits compared to acarbose and gliclazide.
| Cpd. No. | AMES toxicity | Max. tolerated dose (human) (log mg/kg/day) | hERG I inhibitor | hERG II inhibitor | Oral Rat Acute Toxicity (LD50) (mol/kg) | Oral Rat Chronic Toxicity (LOAEL) (log mg/kg_bw/day) |
|---|---|---|---|---|---|---|
| 4 | Yes | −0.409 | No | No | 2.682 | 0.862 |
| 6 | No | 0.187 | No | Yes | 2.672 | 0.733 |
| 8 | No | 0.093 | No | Yes | 2.816 | 0.74 |
| 16 | No | −0.204 | No | Yes | 2.505 | 0.745 |
| Acarbose | No | 0.616 | No | Yes | 3.176 | 7.01 |
| Gliclazide | No | −0.04 | No | No | 1.932 | 1.745 |
