Table 1. Pathways in each tumor region of ESCC.
| GO terms | P value | Associated genes | |
|---|---|---|---|
| PtA | |||
| T1A | Intracellular estrogen receptor signaling pathway | 3.00E-04 | CRIPAK, POU4F2, RARA |
| T2A | Secretory granule membrane | 2.30E-03 | ABCC4, PAM, PCSK4 |
| DNA packaging complex | 1.60E-03 | H1FOO, HIST1H3D, PXDNL, SMC4 | |
| T3A | Myosin complex | 2.50E-03 | MYH11, MYO18A, MYO18B |
| Negative regulation of translation | 1.80E-03 | EIF2AK4, RARA, TIA1 | |
| T4A | O-linked glycosylation of mucins | 9.80E-04 | |
| Termination of O-glycan biosynthesis | 3.00E-04 | MUC17, MUC5B, MUC6 | |
| O-glycan processing | 2.20E-03 | ||
| Sectetory granule membrane | 1.60E-03 | ABCC4, DBH, PAM | |
| PtB | |||
| T1B | Transport of mature transcript to cytoplasm | 9.10E-03 | NUP153, NXF1, SRRM1 |
| Transport of mature mRNA derived from an intron-containing transcript | 1.40E-02 | ||
| Melanoma | 8.40E-03 | HGF, PIK3R2, TP53 | |
| ECM proteoglycans | 1.20E-02 | DSPP, MUSK, TNC | |
| T2B | Melanoma | 3.10E-03 | HGF, PIK3R2, TP53 |
| T3B | Ribosome biogeneisis in eukaryotes | 4.00E-03 | BMS1, HEATR1, NXF1, REXO1 |
| ECM-receptor interaction | 2.80E-03 | COL11A1, GP1BA, THBS2, TNC | |
| Melanoma | 7.50E-03 | HGF, PIK3R2, TP53 | |
| T4B | NEP/NS2 interacts with the cellular export machinery | 4.10E-04 | NUP153, NUP210, XPO1 |
| Rev-mediated nuclear export of HIV RNA | 3.00E-04 | ||
| Export of viral ribonucleoproteins from nucleus | 3.40E-04 | ||
| Interactions of Rev with host cellular proteins | 2.00E-04 | ||
| M | Prolactin signaling pathway | 6.30E-03 | CSN2, ESR1, PIK3R2 |
| Melanoma | 1.20E-02 | HGF, PIK3R2, TP53 | |
| Muscle contraction | 6.70E-03 | MYL9, NEB, TPM2 | |
Abbreviations: ESCC, esophageal squamous cell carcinoma; PtA, patient A; PtB, patient B.