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. Author manuscript; available in PMC: 2016 Nov 25.
Published in final edited form as: Cell Syst. 2015 Nov 25;1(5):326–337. doi: 10.1016/j.cels.2015.11.001

Figure 1. Gene expression analysis identifies mixed-tissue gene signatures.

Figure 1

(A) Unsupervised hierarchical clustering of a cohort of Alopecia Areata patchy (AAP), totalis/universalis (AT/AU), and unaffected controls (Normal) using the Alopecia Areata gene signature (AAGS). Blue, underexpression; Red, overexpression. (B) Gene co-similarity matrix showing gene clusters. Stronger orange indicates lower dissimilarity in gene expression. Clusters over- and under-expressed in Alopecia Areata are indicated. (C) Graphical representation of genes in the signature and the statistically enriched functional categories associated with them. Blue indicates signaling pathways; yellow, immune/inflammation pathways; orange, HLA; and red indicates cell death pathways. Pathways at p<0.05 FDR corrected were kept for this analysis.