Skip to main content
. 2015 Dec 7;5:17732. doi: 10.1038/srep17732

Figure 8. Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation.

Figure 8

The activation of PI3K/Akt pathway by RANKL stimulates the Ser9 phosphorylation of GSK3β (1), which in turn induces the nuclear-cytoplamic translocation of hnRNPK mediated by ERK activity (2), and thereby enhances GSK3β-hnRNPK interaction (3). This interaction, on one hand, is required for the activation of NF-κB pathway and the expression of NFATc-1, which results in the expression of the osteoclast specific genes (4), and on the other hand, is involved in the acetylation of α-tubulin that is important for the fusion between the maturing osteoclasts and the resorbing ability of the mature osteoclasts (5).