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. 2015 Dec 7;5:17470. doi: 10.1038/srep17470

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(A) Scheme of the double transgenic approach. (B) Images of control and bitransgenic mice (left) and immunostaining of the CA1 subfield using α-VP16 antibody (right). Scale bar: 20 μm (C) Nissl staining of wt and caSRF animals. Left panels: Gross abnormalities of cortical somas in caSRF mice. Scale bar: 100 μm. Right panels: Hydrocephalia in caSRF animals. Ctx: cortex, Vz: ventricle, Hp: hippocampus. Scale bar: 500 μm. (D) Golgi staining showing the abnormal orientation of apical dendrites in principal cortical neurons (red arrowheads) of caSRF bitransgenics. Scale bar: 100 μm.