Skip to main content
. 2015 Dec 7;5:16683. doi: 10.1038/srep16683

Figure 3. TLR4 deficiency results in diminished experimental acquired cholesteatoma-derived bone destruction and hearing loss.

Figure 3

(A) The progression of experimental cholesteatoma, as detected by anatomical microscopy. WT,TLR2−/−, and TLR4−/− mice showed normal tympanic membraneswith clearly visible ossicles through the smooth, transparent tympanic membrane. At 6 weeks postoperatively, the tympanic membrane thickened in the pars flaccida, with cholesteatoma formation behind the tympanic membrane (n = 13). Black asterisks indicatethe malleus that could be observed through the smooth, transparent tympanic membrane, while white asterisks indicatecholesteatoma behind the tympanic membrane. (B) TLR4−/− mice showed markedly reduced bone destruction scores compared withWT mice (n = 13). (C) Representative images of bullae harvested fromWT, TLR2−/−,and TLR4−/− mice. Scale bars denote 200 μm (n = 8).