Systemic function of DILPs during larval development and its regulation by multiple factors (see text for details).
DILP, Drosophila insulin-like peptide; E, ecdysone; 20E, 20-hydroxyecdysone (active form of ecdysone); FDS, fat body-derived signal; SDR, secreted decoy of insulin receptor; Imp-L2, ecdysone-inducible gene L2; ALS, acid-labile subunit; mNSCs, median neurosecretory cells; BR, brain; GC, glial cells; PG, prothoracic gland; CC, corpora cardiaca; ID, imaginal discs; FB, fat body.