Fig. 5.

Poly-ICLC induces upregulation of costimulatory molecules on LC similar to Poly-ICR. Immature LC were left untreated or exposed to HPV16 VLP prior to treatment with s-Poly-I:C (Poly-ICR or Poly-ICLC). Control cells were left untreated or were exposed to HPV16. Expression of CD40, CD80, CD83, and CD86 and was then analyzed by flow cytometry. The average fold increase in LC surface marker expression from one representative donor out of four tested is presented. Data shown is the mean fold increase in surface marker expression (±SD) of triplicate values relative to untreated LC based on MFI. ^⁎p=0.05 (Mann–Whitney U test).