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. 2015 Dec 7;5:17807. doi: 10.1038/srep17807

Figure 1. A schematic showing the experimental design and the time-line of vehicle (VEH) or resveratrol (RESV) treatment.

Figure 1

Status epilepticus (SE) was first induced in Fischer 344 rats through graded intraperitoneal injections of Kainic acid (KA). Animals received hourly injections of VEH or RESV for three hours on the day of SE (Day 1), which commenced an hour after the onset of SE. In the following 3 days (days 2–4), animals received twice daily (morning and evening) injections of VEH or RESV. The behavioral seizures in both VEH and RESV treated groups were terminated 2 hours after the induction of SE through an intraperitoneal injection of diazepam (5 mg/Kg). Subgroups of animals were euthanized 1 and 4 days after SE along with age-matched naïve control animals and tissues harvested for biochemical and molecular biological studies. Additional subgroups of animals were euthanized 4 days after SE via intracardiac perfusions for various immunohistochemical studies. M, morning; E, evening.