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. 2015 Nov 9;195(12):5592–5601. doi: 10.4049/jimmunol.1501929

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Copyright © 2015 by The American Association of Immunologists, Inc.

This article is distributed under The American Association of Immunologists, Inc., Reuse Terms and Conditions for Author Choice articles.

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FIGURE 7. — Recovery of IgG-type BCR expression on PBMCs collected after a single i.v. dose of 0.24 mg/kg BW IdeS in a human healthy subject. Flow cytometry analysis of CD19⁺/IgG⁺ cells at different time points after a single dose of IdeS. PBMCs were purified, and lymphocytes gated using forward scatter/side scatter (P1). B cells (CD19⁺) were monitored in FL2 (PE), and IgG was monitored in FL4 (allophycocyanin). Double-positive cells for CD19 (PE) and the Fc portion of IgG (FL4) predose and up to 96 h postdosing (upper panels). Double-positive cells for CD19 (FL2) and the Fab portion of IgG (FL4) predose and up to 96 h postdosing (lower panels). MFI for double-positive cells are given for R1 (CD19/anti-Fc) and R2 (CD19/anti-Fab). The data are representative of two staining experiments.