Table 1.
The effects of sesamin treatment on serum levels of testosterone, renal injury, and inflammatory biomarkers in cisplatin-intoxicated rats.
| Control | CP | CP + sesamin (10 mg/kg) | CP + sesamin (20 mg/kg) | |
|---|---|---|---|---|
| Urea (mg/dL) | 23.1 ± 1.15a | 64.14 ± 2.2b | 38.7 ± 1.6c | 29.4 ± 1.5a |
| Creatinine (mg/dL) | 0.61 ± 0.03a | 3.14 ± 0.15b | 1.98 ± 0.12c | 0.76 ± 0.05a |
| IL-1 (pg/mL) | 130.3 ± 8.11a | 573.4 ± 20.3b | 313.6 ± 12.6c | 161.2 ± 9.9a |
| IL-6 (pg/mL) | 94 ± 2.36a | 606.5 ± 16.5b | 316.9 ± 4.5c | 137 ± 5.2d |
| TNF-α (pg/mL) | 95.2 ± 3a | 377.7 ± 14.4b | 197.2 ± 10.5c | 108.4 ± 5.9a |
| Testosterone (ng/mL) | 0.83 ± 0.04a | 0.22 ± 0.01b | 0.41 ± 0.02c | 0.72 ± 0.02d |
CP: cis-diamminedichloroplatinum/cisplatin; IL: interleukin; TNF-α: tumor necrosis factor-α.
Data are presented as means ± SEM (n = 8). Means within the same row carrying different superscripts are significantly different at (p < .05).