Table 2.
The effects of sesamin treatment on renal tissue lipid peroxidation and antioxidant compounds in cisplatin-intoxicated rats.
| Control | CP | CP + sesamin (10 mg/kg) | CP + sesamin (20 mg/kg) | |
|---|---|---|---|---|
| MDA (nmol/g) | 81.12 ± 2.9a | 154.4 ± 5.3b | 116.7 ± 3.9c | 93.13 ± 2.06a |
| NO (μmol/g) | 56.2 ± 1.4a | 101 ± 2.7b | 72.6 ± 2.8c | 60.6 ± 2.6a |
| GSH (μmol/g) | 7.9 ± 0.19a | 3.5 ± 0.22b | 5.5 ± 0.16c | 7.4 ± 0.18a |
| GPx (U/g) | 37.2 ± 1.12a | 18.2 ± 1.34b | 26.6 ± 0.98c | 34.12 ± 1.1a |
| SOD (U/g) | 62.6 ± 2.6a | 31.9 ± 1.2b | 48.7 ± 2.3c | 58 ± 2.25a |
| CAT (U/g) | 5.2 ± 0.25a | 2.7 ± 0.07b | 3.7 ± 0.13c | 4.6 ± 0.13a |
CAT: catalase; CP: cis-diammine-dichloroplatinum/cisplatin; GPx: glutathione peroxidase; GSH: glutathione; MDA: malondialdehyde; NO: nitric oxide; SOD: superoxide dismutase.
Data are presented as means ± SEM (n = 8). Means within the same row carrying different superscripts are significantly different at (p < .05).