Table 3.
The effects of sesamin treatment on testicular tissue lipid peroxidation and antioxidant compounds in cisplatin-intoxicated rats.
| Control | CP | CP + sesamin (10 mg/kg) | CP + sesamin (20 mg/kg) | |
|---|---|---|---|---|
| MDA (nmol/g) | 203.6 ± 7.5a | 585.2 ± 20.1b | 295.4 ± 8.8c | 233.8 ± 5.2a |
| NO (μmol/g) | 77.1 ± 2.1a | 171.4 ± 3.66b | 122 ± 2.4c | 90.3 ± 3.8d |
| GSH (μmol/g) | 6.6 ± 0.23a | 4.85 ± 0.36b | 5.48 ± 0.3ab | 6.2 ± 0.22a |
| GPx (U/g) | 10.04 ± 0.24a | 4.01 ± 0.31b | 6.3 ± 0.2c | 9.3 ± 0.32a |
| SOD (U/g) | 75.4 ± 2.9a | 35.6 ± 1.1b | 51.5 ± 1.7c | 65.6 ± 2.4d |
| CAT (U/g) | 21.6 ± 1.2a | 10.8 ± 0.54b | 15.6 ± 0.5c | 19.7 ± 1.1a |
CAT: catalase; CP: cis-diammine-dichloroplatinum/cisplatin; GPx: glutathione peroxidase; GSH: glutathione; MDA: malondialdehyde; NO: nitric oxide; SOD: superoxide dismutase.
Data are presented as means ± SEM (n = 8). Means within the same row carrying different superscripts are significantly different at (p < .05).