Figure 3.

CDK5miR prevents learning and memory deficits 1 month after ischemia. Spatial learning and memory function were assessed with the Morris water maze test. (A) (a) Learning: average latency to find the hidden platform, (b) distance traveled to reach the platform, and (c) representative routes used to find the hidden platform in the final trial. (B) During the probe trial, (a) the latency to reach the exact platform location and (b) the number of crossings over the platform site was determined. (C) (a) Latency to reach the platform during reversal learning was established. (b) Quadrants of platform location were established as follows: quadrant A (position in learning) and quadrant B (position in reversal learning), with quadrants C and D outside the platform positions. (c) A representative route patterns traveled during the reversal learning test is shown, and the number of crossings in each quadrant during each trial in the reversal learning period were established. The data are expressed as the group mean±s.e.m. *, **Significant differences: *P<0.05, **P<0.001; n= 12 to 15 animals/group. CDK5, cyclin-dependent kinase 5; SCR, scrambled RNA sequence.