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. 2015 Jun 24;35(12):1937–1949. doi: 10.1038/jcbfm.2015.150

Figure 4.

Figure 4

Figure 4

Cyclin-dependent kinase 5 (CDK5) silencing reduces neurodegenerative hallmarks in CA1 area at 1 month after ischemia. (A) Representative immunoreactivity levels from the ipsilateral CA1 region of the hippocampus (bregma −2.56) at 1 month after ischemia are shown. The micrographs were obtained at × 10 and × 40. Scale bars: 50 μm ( × 10) and 25 μm ( × 40). (B) Immunoreactivity or fluorescence intensities of (a) NeuN, (b) BAX, (c) GFAP, (d) OX42, (e) AT8, (f) microtubule-associated protein 2 (MAP2), and (g) pCREB. These values were quantified at bregma levels of −2.56, −3.60, and −5.20. *Significant differences, P⩽0.05; n=4 to 6 animals/group. CREB, cyclic AMP response element-binding protein; RU, relative unit; SCR, scrambled RNA sequence.