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. 2015 Jul 29;35(12):2021–2031. doi: 10.1038/jcbfm.2015.167

Figure 1.

Figure 1

Effect of recombinant tissue-type plasminogen activator treatment on Evans blue extravasation in mice with middle cerebral artery occlusion. (A) Evans blue (EB) extravasation after different durations (6, 9, 12, 24, or 72 hours) of recombinant tissue-type plasminogen activator (rt-PA) treatment (10 mg/kg), all initiated at 4 hours after permanent middle cerebral artery (MCA) occlusion. Sham operation (hatched dots) indicates rt-PA-treated mice without MCA occlusion. (B) The EB extravasation after 2-hour rt-PA treatment, which was initiated 1, 4, 7, 22, or 70 hours after permanent MCA occlusion. The numbers in parentheses indicate the time points of the rt-PA treatment after MCA occlusion and the time from rt-PA treatment until euthanization. Bars represent median value. *P<0.05 (Mann–Whitney U-test).