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. 2015 Jul 15;35(12):2043–2051. doi: 10.1038/jcbfm.2015.169

Figure 5.

Figure 5

12/15-lipoxygenase (12/15-LOX) mRNA is increased after ischemia-reperfusion, which is accompanied by early phosphorylation of STAT1 and STAT6. (A) In a mouse transient focal ischemia model, 12/15-LOX mRNA is increased compared with sham (S), after 45 minutes of ischemia and 24 hours of reperfusion (IR). *P<0.05 (n=6 in S, n=9 in IR). (B) STAT1 is phosphorylated at early time points after 45 minutes ischemia with 1 and 3 hours of reperfusion in the mouse cortex. *P<0.05 versus sham (n=3 per group). (C) Similarly, p-STAT6 is elevated at early time points. *P<0.05 versus sham (n=3 per group). Data are mean±s.e.m. Student's t-test (A) or one-way ANOVA with Bonferroni's multiple comparison test (B and C) was used to compare groups. STAT, Signal Transducers and Activators of Transcription.