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. 2015 May 15;123(12):1294–1301. doi: 10.1289/ehp.1409396

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Plot of geometric mean (95% CI) plasma and red blood cell folate (nmol/L) by treatment group and time in the first phase and second phase of the trial. In the second phase, there are two values (white and black shapes) for each folic acid group: the white shapes represent the subset of participants in the folic acid groups that continued on folic acid, and the black shapes represent the subset of the participants in the folic acid groups that switched to placebo. Blood for measurement of folate was collected only at baseline, week 12, and week 24; intermediate time points are not available; therefore, the lines do not represent linear trends.