Figure 2.
The Hazard Identification Approach to Breast Carcinogens (HIA‑BC). Abbreviations: AGD, anogenital distance; AR, androgen receptor; ER, estrogen receptor; OECD TG 473, OECD Test No. 473: In Vitro Mammalian Chromosomal Aberration Test (OECD 2014a); OECD TG 487, OECD Test No. 487: In Vitro Mammalian Cell Micronucleus Test (OECD 2014b); RIA, radioimmunoassay; TEB, terminal end bud. *Cell cycle changes are indicators consistent with the hallmarks of cancer progression identified by Hanahan and Weinberg (2000, 2011). **Assessed in mammary epithelial tissue after either in vitro or whole animal exposure.