Figure 5.

The combination of K3 CpG and cGAMP efficiently suppresses tumors in the EG-7 and B16 F10 mouse tumor models. (A) Mice were injected with 1 × 10⁶ EG-7 lymphoma cells (in 100 μL of PBS) s.c. on day 0. On days 7 and 10, mice were given intratumor injections of PBS (n = 8), K3 CpG (n = 8), cGAMP (n = 8), or K3 CpG + cGAMP (n = 9), and were monitored for tumor growth for 22 days. (B) Mice were injected with 0.5 × 10⁶ B16 F10 cells (in 100 μL of PBS) s.c. on day 0. On days 8, 11, and 13, mice were given intratumor injections of PBS (n = 8), K3 CpG (n = 8), cGAMP (n = 8), or K3 CpG + cGAMP (n = 8), and mice were monitored for tumor growth for 17 days. Data are representative of two independent experiments and are shown as the mean + SEM of biological replicates from one experiment, representative of two performed. *p < 0.05; **p < 0.01 (Mann–Whitney U-test).