Table 1. Serious adverse drug reactions in children and adolescents (selected reports/notifications to AkdÄ).

Substance	Sequelae	Cause
Dimenhydrinate	Deaths in infants/toddlers	Licensed dose exceeded
α -adrenergic nasal drops	Coma in neonates	Dose exceeded/incorrect concentration administered
Phosphate-containing enemas	Deaths in infants/toddlers	Contraindication in children not heeded <6 years
ACE inhibitors, sartans	Intrauterine damage	Contraindication in pregnant women not heeded
Methylphenidate	Terminal liver failure	Insufficient monitoring in long-term treatment

AkdÄ, Drug Commission of the German Medical Association (Arzneimittelkommission der Ärzteschaft); ACE, angiotensin converting enzyme