Table 2.

Redox-sensitive cysteines of STAT3.

Residues (domain)	Function
C259 (NTD)	Responsible for cell lysis- and peroxide-induced dimers (57)
C328 (DBD), C542 (LD)	Glutathionylation blocks JAK2-mediated Y705 phosphorylation (56)
C418/C426/C488 (DBD), C765 (TAD)	Oxidation decreased DNA binding, SIE/c-fos promoter activity, and cell proliferation. Contribute (in various combinations) to peroxide-induced tetramer formation (59)
C418 (DBD), C712/C718 (TAD), C765 (TAD)	Responsible for Prx2-induced dimers and tetramers (58)

DBD, DNA-binding domain; LD, linker domain; NTD, N terminus domain; TAD, transcription activation domain.