Figure 10.
Simulations of mSOD1-like (morph) and (morph + Rm) models for MN 3 with Ih current included in the model. Rin was measured as the ratio of the change in somatic membrane potential (difference between the steady-state membrane potential and the resting membrane potential, Vss) to the amplitude of the current pulse. Note that the resting membrane potential was affected by Ih. When morphology increase was included in the mSOD1-like (morph) model, Rin was reduced by 15%. To further reduce Rin by nearly 30% similar to experimental data, Rm needed to be reduced in mSOD1-like (morph + Rm) model by 40%. The inset shows how the sag ratio was measured in the simulations.