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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Endocr Relat Cancer. 2015 Nov 9;23(1):53–63. doi: 10.1530/ERC-15-0417

Figure 1. The effects of S3I-201 on thyroid tumor growth and survival of HFD-wild type and HFD-ThrbPV/PVPten+/− mice.

Figure 1

(A) Survival curves for HFD- ThrbPV/PVPten+/− mice treated with S3I-201 (5 mg/kg body weight, n=12) or vehicle (0.05% DMSO, n=12)) I.P. injection 3 times a week from 8 weeks of age until they had to be euthanized because of sickness. Data are presented by Kaplan-Meir methods and analyzed by log-rank test. The p values are indicated. (B) Thyroid weights of vehicle-treated or S3I-201-treated wild type (n=10–11) or ThrbPV/PVPten+/− mice (n=10–13). (C-I). Comparison between the two groups of representative microphotographs of immunohistochemistry (IHC) one using anti-Ki67 antibody on thyroid sections from wild type mice with/without S3I-201 (panels a, b, c and d) and one without the treatment with primary antibodies are shown in the corresponding panels (a and c). The thyroid sections from ThrbPV/PVPten+/− mice (e, f, g, and h) and the negative without the treatment with primary antibodies are shown in the corresponding panels (e and g). (C-II) The Ki67-positive cells were counted and the data expressed as percentage of Ki67-positive cells versus total cells. The data are expressed as mean ± SE (n=2 slides). The p values are shown.