Table 3.
Genotype distribution of TNF-α single nucleotide polymorphisms (SNPs) based on endometriosis stages
| Genotype | Control (65) | Stage II (29) | Stage III (31) | Stage IV (5) | Total (130) | P value |
|---|---|---|---|---|---|---|
| -1031 T/C | ||||||
| TT | 48 | 17 | 15 | 4 | 84 | 0.42 |
| TC | 17 | 8 | 7 | 1 | 33 | |
| CC | 0 | 4 | 9 | 0 | 13 | |
| -238 G/A | ||||||
| GG | 36 | 11 | 15 | 1 | 63 | 0.076 |
| GA | 22 | 17 | 10 | 4 | 53 | |
| AA | 7 | 1 | 6 | 0 | 14 | |
| -308 G/A | ||||||
| GG | 65 | 29 | 31 | 5 | 130 | 1.00 |
| GA | 0 | 0 | 0 | 0 | 0 | |
| AA | 0 | 0 | 0 | 0 | 0 | |
-1031 T/C (P=0.42, χ2=3.9, df= 4), -238 G/A (P=0.076, χ2 = 8.5, df=4), -308 G/A (P=1.00).
χ2; Chi-square, df; Degree of freedom and TNF-α; Tumor necrosis factor-alpha.