Table 1.
Examples of Metabolic Enzymes Identified as RBPs in the RNA Interactome Studies
| Gene Name | Complete Name | Function | Di/mononucleotide Binding | HeLa RNA Interactome | HEK293 RNA Interactome | mESC RNA Interactome |
|---|---|---|---|---|---|---|
| ADK | Adenylate kinase | AMP biosynthesis | ATP and adenosine | Yes | ||
| ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase | Biosynthesis of proline, ornithine, and arginine | ATP and NADP | Yes | ||
| ALDH6A1 | Methylmalonate-semialdehyde dehydrogenase (acylating), mitochondrial | Valine and pyrimidine metabolism | NAD(P)/H | Yes | ||
| ALDOA | Fructose-bisphosphate aldolase A | Glycolysis | Yes | |||
| ASS1 | Argininosuccinate synthase | l-Arginine biosynthesis | ATP | Yes | ||
| CCBL2 | Kynurenine–oxoglutarate transaminase 3 | Transaminase activity for several amino acids | Yes | |||
| CS | Citrate synthase, mitochondrial | TCA cycle | Yes | |||
| DUT | Deoxyuridine 5′-triphosphate nucleotidohydrolase, mitochondrial | Nucleotide metabolism | dUTP | Yes | Yes | |
| ENO1 | α-Enolase | Glycolysis | Yes | Yes | ||
| FASN | Fatty acid synthase | Fatty acid synthesis | NADP/H | Yes | Yes | |
| FDPS | Farnesyl pyrophosphate synthase | Formation of farnesyl diphosphate | Yes | |||
| GOT2 | Aspartate aminotransferase, mitochondrial | Amino acid metabolism | Yes | |||
| HADHB | Trifunctional enzyme subunit beta, mitochondrial | beta-Oxidation of fatty acids | Yes | |||
| HK2 | Hexokinase-2 | Glycolysis | ATP | Yes | ||
| HSD17B10 | 3-Hydroxyacyl-CoA dehydrogenase type-2 | β-Oxidation at position 17 of androgens and estrogens | NAD/NAD(P) | Yes | ||
| LTA4H | Leukotriene A4 hydrolase | Biosynthesis of leukotriene B4 | Yes | |||
| MDH2 | Malate dehydrogenase 2, mitochondrial | TCA cycle | NAD/H | Yes | Yes | |
| NME1 | Nucleoside diphosphate kinase A | Synthesis of nucleoside triphosphates | ATP | Yes | ||
| NQO1 | NAD(P)H dehydrogenase (quinone) 1 | Detoxification pathways and vitamin K-dependent γ-carboxylation of glutamate residues | NAD(P)H | Yes | ||
| PKM2 | Pyruvate kinase | Glycolysis | ATP | Yes | Yes | |
| PPP1CC | Serine/threonine–protein phosphatase 1–γ catalytic subunit | Glycogen metabolism, muscle contractility, and protein synthesis | Yes | |||
| SUCLG1 | Succinyl-CoA ligase (ADP/GDP-forming) subunit α, mitochondrial | TCA cycle | ATP/GTP | Yes | ||
| TPI1 | Triosephosphate isomerase | Glycolysis and gluconeogenesis | Yes |