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. Author manuscript; available in PMC: 2015 Dec 7.
Published in final edited form as: J Gynecol Res. 2015 Apr 24;1(1):103. doi: 10.15744/2454-3284.1.103

Figure 2.

Figure 2

Working hypothetical model showing how BRCA1/1a binding to Ubc9 induces Caveolin-1 expression, down regulates VEGF regulates endothelial function in normal ovaries and fallopian tubes. In HGSEOC with BRCA1 dysfunction, Ubc9 is unleashed which inhibits Caveolin-1 expression causing increased levels of VEGF, loss of endothelial function and accumulation of ascites due to dissemination of cancer cells to the peritoneal cavity resulting in HGSEOC