Table 2. Comparison of the Clinicopathological Characteristics of Patients With Signet-Ring Cell Carcinoma (SRC) and non-signet ring cell carcinoma (NSRC).
| Variables | SRC n = 138 | NSRC n = 1326 | P |
|---|---|---|---|
| Gender | 0.003 | ||
| Male | 81 | 941 | |
| Female | 57 | 385 | |
| Age (yr) | 0.014 | ||
| <60 | 86 | 681 | |
| ≥60 | 52 | 645 | |
| Tumor size (cm) | 0.851 | ||
| <5 | 84 | 818 | |
| ≥5 | 54 | 508 | |
| Tumor location | <0.001 | ||
| Upper third | 22 | 484 | |
| Middle third | 34 | 214 | |
| Lower third | 68 | 565 | |
| Two-third or more | 14 | 63 | |
| Venous tumor emboli | 0.501 | ||
| Yes | 53 | 471 | |
| No | 85 | 855 | |
| Nervous invasion | 0.602 | ||
| Yes | 56 | 508 | |
| No | 82 | 818 | |
| Serosa invasion | 0.344 | ||
| Yes | 69 | 607 | |
| No | 69 | 719 | |
| Lymph node metastasis | 0.325 | ||
| Yes | 96 | 867 | |
| No | 42 | 459 | |
| TNM stage | <0.001 | ||
| Stage I | 35 | 311 | |
| Stage II | 13 | 327 | |
| Stage III | 90 | 688 | |
| Family history of gastric cancer | 0.876 | ||
| Yes | 10 | 101 | |
| No | 128 | 1225 | |
| P21 expression | <0.001 | ||
| Positive | 66 | 883 | |
| Negative | 72 | 443 | |
| P53 expression | 0.009 | ||
| Positive | 86 | 966 | |
| Negative | 52 | 360 | |
| c-myc expression | 0.111 | ||
| Positive | 79 | 850 | |
| Negative | 59 | 476 | |
| EGFR expression | 0.292 | ||
| Positive | 49 | 532 | |
| Negative | 89 | 794 |