Table 2. Prevalence of abdominal symptoms according to PLD disease severity.

	No or mild	Moderate	Severe	P value a
Responder of symptom questionnaire(n)	201	38	14
Pressure-related symptoms (%)
Abdominal fullness	34.8	76.3	92.9	<0.001
Mass sensation	15.4	73.7	85.7	<0.001
Dyspnea or chest discomfort	35.8	55.3	64.3	0.004
Early satiety	12.9	52.6	78.6	<0.001
Pain (%)
RUQ pain	30.8	68.4	92.9	<0.001
Back pain	52.0	63.2	78.6	0.028
Flank pain	48.3	63.2	50.0	0.294
Taking analgesics	5.5	23.7	21.4	<0.001
GI symptoms (%)
Epigastic soreness	27.9	47.4	57.1	0.025
Anorexia	29.0	39.5	57.1	0.019
Nausea or vomiting	13.9	31.6	35.7	0.002
Presence of * moderate to severe symptoms
Pressure-related symptoms (%)
Abdominal fullness	3.0	42.1	78.6	<0.001
Early satiety	3.0	39.5	50.0	<0.001
Dyspnea or chest discomfort	1.0	10.5	14.3	<0.001
Pain (%)
RUQ pain	3.0	26.3	50.0	<0.001
Back pain	3.0	26.3	35.7	<0.001
Flank pain	2.0	10.5	7.1	0.025
Taking analgesics	0.5	15.8	7.1	<0.001
GI symptoms (%)
Anorexia	1.5	18.4	21.4	<0.001
Epigastic soreness	1.0	15.8	0.0	0.011
Nausea or vomiting	1.7	7.9	14.3	0.001

^a Chi-square test for trend; None or mild PLD, htTLV<1,600 mL/m; Moderate PLD, 1,600≤ htTLV <3,200mL/m; Severe PLD, htTLV≥3,200 mL/m;

* Moderate to severe symptoms: score 2 or 3.

PLD, polycystic liver disease; RUQ, right upper quadrant, GI, gastrointestinal.