Table 3. The associations of total homocysteine (quartiles) with PWMHs and DWMHs.

	PWMHs†		DWMHs‡
	OR (95% CI)	P value	OR (95% CI)	P value
Age	1.072(1.058;1.088)	<0.001	1.042(1.025; 1.059)	<0.001
Hypertension	1.948(1.443; 2.629)	<0.001	---	NS
Prior stroke	2.187(1.556; 3.076)	<0.001	1.588(1.077; 2.343)	0..020
tHcy(μmol/L)*		0.035		NS
Quartile 1	Reference	---	Reference	---
Quartile 2	1.530(1.020; 2.295)	0.040	---	NS
Quartile 3	1.581(1.053; 2.347)	0.027	---	NS
Quartile 4	1.761(1.172; 2.648)	0.007	---	NS

^† Included covariables:age, hypertension, prior stroke, Systolic blood pressure, haemoglobin, hematocrit, estimated glomerular filtration rate, triglyceride high density lipoprotein cholesterol and total homocysteine.

^‡ Included covariables:age, hypertension, prior stroke, alcohol use, Systolic blood pressure, diastolic blood pressure, haemoglobin, fasting plasma glucose, estimated glomerular filtration rate.

*tHcy levele was divided by quartiles: quartile 1, tHcy < 13.0μmol/L; quartile 2, tHcy 13.0 to 16.5 μmol/L; quartile 3, tHcy 16.5 to 22.13 μmol/L; quartile 4, tHcy > 22.13 μmol/L. The lowest quartile was set as a reference, the other quartiles are compared to the lowest quartile.

Abbreviations: PWMHs, periventricular white matter hyperintensities; DWMHs, deep white matter hyperintensities; ARWMC, age-related white matter changes; tHcy, total homocysteine; NS, no significance.