Table 1. Top adverse effects for cholinesterase inhibitors in FAERS database.
| Top Adverse Effects | Drug specific reports | AChEI class reports | Specific drug frequency (%) | AChEI class frequency (%) |
|---|---|---|---|---|
| rivastigmine– 5918 total reports | ||||
| Death | 995 | 1216 | 16.81 | 12.31 |
| Vomiting | 472 | 690 | 7.98 | 6.99 |
| Fall | 417 | 638 | 7.05 | 6.46 |
| Nausea | 374 | 557 | 6.32 | 5.64 |
| Confusional State | 361 | 475 | 6.10 | 4.81 |
| Dizziness | 256 | 381 | 4.33 | 3.86 |
| Pneumonia | 253 | 373 | 4.28 | 3.78 |
| Diarrhoea | 245 | 375 | 4.14 | 3.80 |
| Hallucination | 224 | 305 | 3.79 | 3.09 |
| Malaise | 219 | 304 | 3.70 | 3.08 |
| donepezil– 2221 total reports | ||||
| Bradycardia | 178 | 338 | 8.01 | 3.42 |
| Fall | 139 | 638 | 6.26 | 6.46 |
| Vomiting | 122 | 690 | 5.49 | 6.99 |
| Syncope | 118 | 343 | 5.31 | 3.47 |
| Convulsion | 99 | 240 | 4.46 | 2.43 |
| Nausea | 99 | 557 | 4.46 | 5.64 |
| Death | 95 | 1216 | 4.28 | 12.31 |
| Electrocardiogram QT prolonged | 94 | 130 | 4.23 | 1.32 |
| Rhabdomyolysis | 94 | 114 | 4.23 | 1.15 |
| Drug Interaction | 86 | 183 | 3.87 | 1.85 |
| galantamine– 1738 total reports | ||||
| Death | 126 | 1216 | 7.25 | 12.31 |
| Vomiting | 96 | 690 | 5.52 | 6.99 |
| Nausea | 84 | 557 | 4.83 | 5.64 |
| Fall | 82 | 638 | 4.72 | 6.46 |
| Medication Error | 71 | 102 | 4.09 | 1.03 |
| Decreased Appetite | 64 | 304 | 3.68 | 3.08 |
| Loss of consciousness | 61 | 248 | 3.51 | 2.51 |
| Dizziness | 59 | 381 | 3.39 | 3.86 |
| Bradycardia | 57 | 338 | 3.28 | 3.42 |
| Confusional State | 56 | 475 | 3.22 | 4.81 |