Table 4.

Change in 6-minute walk distance (6MWD) and time to clinical worsening (TCW) by menopausal status

	Tadalafil		Placebo
Age group, parameter	n	Mean (SD)	n	Mean (SD)
Premenopausal (14–44 years old)
Change in 6MWD, m	61	45.7 (55)	21	22.7 (45)
TCW, days	6	50.2 (31)	2	43 (20)
Perimenopausal (45–55 years old)
Change in 6MWD, m	52	41.1 (50)	12	33.4 (45)
TCW, days	4	84.5 (13)	1	29
Postmenopausal (>55 years old)
Change in 6MWD, m	97	24.5 (54)	21	0.8 (60)
TCW, days	11	58.3 (28)	7	39.3 (32.5)