Table 1.
Particle size and visual appearance (precipitation or clear) after 24 hours for formulations containing different polymers
| Polymer used in formulation (1:1:20) | Mean size (nm) mean ± SD (PDI) | Visual observation after 24 hours |
|---|---|---|
| TPGS | 842.8±29.31 (0.226±0.215) | Precipitation |
| Kolliphor RH40 | 769.4±41.90 (0.413±0.258) | Precipitation |
| Kolliphor ELP | 1,782.1±343.80 (1.597±0.340) | Precipitation |
| Pluronic L121 | 1,101.2±61.95 (0.722±0.573) | Precipitation |
| Pluronic P123 | 607.5±18.95 (0.246±0.136) | Precipitation |
| Pluronic F127 | 1,051.8±66.74 (0.711±0.109) | Precipitation |
| Pluronic F87 | 719.7±24.21 (0.599±0.121) | Precipitation |
| Pluronic F68 | 1,560.1±182.28 (0.623±0.132) | Precipitation |
| Pluronic F108 | 1,117.2±7.15 (0.554±0.315) | Precipitation |
| DSPE-PEG2K | 149.5±0.40 (0.605±0.033) | Clear |
Note: Ratio of polymers in the micelle formula, amphotericin B:lecithin:polymer =1:1:20.
Abbreviations: PDI, polydispersion index; TPGS, d-alpha tocopheryl polyethylene glycol succinate; DSPE-PEG2K,1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(poly(ethylene glycol)-2000; SD, standard deviation.