Table 2.
Particle size, polydispersity index, entrapment efficacy, and drug loading for formulations with various DSPE-PEG2K ratios
| Name | AmB:lecithin: DSPE-PEG2K | Mean size (nm) mean ± SD (PDI) | Entrapment efficacy (%) | Drug loading (%) |
|---|---|---|---|---|
| LD0–5 | 1:0:5 | 283.23±45.47 (0.68±0.048) | 94.95 | 15.83 |
| LD1–5 | 1:1:5 | 221.28±9.08 (0.70±0.053) | 83.98 | 12.00 |
| LD2–5 | 1:2:5 | 222.40±7.18 (0.67±0.072) | 44.71 | 5.59 |
| LD0–10 | 1:0:10 | 320.43±10.03 (0.91±0.054) | 96.67 | 8.79 |
| LD1–10 | 1:1:10 | 187.20±10.55 (0.51±0.017) | 90.14 | 7.51 |
| LD1–20 | 1:1:20 | 149.50±0.40 (0.605±0.033) | 92.17 | 4.19 |
| LD2–10 | 1:2:10 | 200.80±6.80 (0.84±0.088) | 66.17 | 5.09 |
Abbreviations: DSPE-PEG2K, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(poly(ethylene glycol)-2000; AmB, amphotericin B; PDI, polydispersion index; SD, standard deviation.