Table 5.

The relationship between the grade 3 and 4 adverse events (AE) and UGT1A1 combination genotypes

Item	Combination genotypes (n)	Combination genotypes (n)	Combination genotypes (n)	Combination genotypes (n)	P-value
Grade 3–4 AE	TA6/6 G/G (38)	TA6/6 G/A (18)	TA6/7 G/G (7)	TA6/7 G/A (4)
Diarrhea	1 (2.6%)	3 (16.7%)	2 (28.5%)	3 (75%)	0.014
Neutropenia	0 (0)	2 (11.1%)	2 (28.5%)	2 (50%)	0.022
Anemia	1 (2.6%)	0 (0)	0 (0)	0 (0)	0.582
Thrombocytopenia	1 (2.6%)	0 (0)	0 (0)	0 (0)	0.746

Abbreviation: UGT, uridine diphosphate glucuronosyltransferase.