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. 2015 Dec;6(6):650–659. doi: 10.3978/j.issn.2078-6891.2015.076

Figure 1.

Figure 1

Feedback reactivation of MAPK signaling. (Left) In BRAF mutant CRCs, at baseline, MAPK pathway activity and ERK activation is driven primarily by mutant BRAF. (Right) Upon addition of a BRAF inhibitor, signaling output from mutant BRAF is blocked and there is a transient suppression of ERK activation and MAPK signaling. However, in some BRAF mutant CRCs, EGFR (and possibly other RTKs) drives feedback activation of RAS and CRAF, leading to reactivation of ERK and restoration of MAPK signaling. MAPK, mitogen-activated protein kinase; BRAF, V-raf murine sarcoma viral oncogene homolog B; CRC, colorectal cancer; EGFR, epidermal growth factor receptor; RTK, receptor tyrosine kinase; RAS, rat sarcoma viral oncogene homolog; CRAF, V-raf-1 murine leukemia viral oncogene homolog 1; MEK, mitogen-activated extracellular signal-related kinase kinase.