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. 2015 Nov;3(19):279. doi: 10.3978/j.issn.2305-5839.2015.11.21

Table 4. Fuhrman grading of renal cell carcinoma (RCC) nuclear.

Fuhrman grade Nuclear morphology and size Nucleus morphology
Grade I Round and uniform, sized about 10 μm, with regular nuclear membrane Absent
Grade II Slightly irregular nuclear membrane, with nuclear sized about 15 μm Inconspicuous (visible at ×40)
Grade III Irregular nuclear membrane, with nuclear sized about 20 μm Conspicuous (visible at ×10)
Grade IV Irregular nuclear membrane, pleomorphic, multi-lobed with clumped chromatin; with nuclear sized at least 20 μm Very prominent